منابع مشابه
Focal Contacts as Mechanosensors
The transition of cell-matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II-driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of foca...
متن کاملFocal adhesions as mechanosensors: a physical mechanism.
Focal adhesions (FA) are large, multiprotein complexes that provide a mechanical link between the cytoskeletal contractile machinery and the extracellular matrix. FA exhibit mechanosensitive properties; they self-assemble and elongate upon application of pulling forces and dissociate when these forces are decreased. We propose a thermodynamic model for the mechanosensitivity of FA, according to...
متن کاملFocal Contacts as Mechanosensors: Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an mDia1-dependent and ROCK-independent Mechanism
The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II–driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of foca...
متن کاملFocal adhesions as mechanosensors: the two-spring model.
Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton. Here we present first steps towards a quantitative understanding of focal adhesions as mechanosensors. It has been shown experimentally that high levels of force...
متن کاملAssembly and mechanosensory function of focal contacts.
Focal contacts, focal complexes and related extracellular matrix adhesions are used by cells to explore their environment. These sites act as mechanosensory 'devices', where internal contractile forces or externally applied force can regulate the assembly of the adhesion site and trigger adhesion-dependent signaling involving Rho-family small G-proteins and other signaling pathways. The molecul...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.153.6.1175